What appearance peptides really do, cost and risk.
Evidence grades, legal status and prices for the peptides people use for skin, fat loss, tanning and muscle. Written for people deciding what to believe, not what to buy.
10 profiles · 45 sources · 0 sponsors
PeptideGrade
- SemaglutideStomach side effects, plus rare serious events$149 to $349A
- Melanotan IIMole changes, with melanoma case reportsNo legal priceC
- BPC-157Human safety is largely unknown$150 to $300C
- GHK-CuInjected forms: immune reactions$15 to $60C
- Collagen peptidesMostly wasted money, and animal or fish allergens$12 to $40B
Start with your goal
Skin3Wrinkles, firmness, hydrationCollagen peptides, GHK-Cu, MatrixylHair2Growth, thickness, lossCollagen peptides, GHK-CuFat loss3Weight, appetite, leannessRetatrutide, Semaglutide, TirzepatideTanning1Colour without the sunMelanotan IIMuscle1Size, lean mass, strengthMK-677Recovery3Injury, soreness, sleepBPC-157, MK-677, TB-500
Four evidence grades, and what they miss
A grade rates the proof for the claim, not safety or legality. Retatrutide earns an A and still has no legal retail product.
A
Large human trials
Big randomized trials with published or regulator-reviewed results.
B
Smaller human trials
Controlled trials exist, but they are small, mixed, sponsor-linked or in the wrong population.
C
Early or weak human data
Mostly lab or animal work, with tiny or poor-quality human studies.
Recent regulator changes
5 Nov 2026 · AustraliaLab tests found products labelled TB-500 with none detectableAustralia's regulator also found retatrutide products holding less than their labels stated.Read the TB-500 profile28 Oct 2026 · United StatesHHS will tolerate compounding of six peptides, including BPC-157It is an interim enforcement policy, not an approval, and FDA's own drug centre recommended against listing them.Read the BPC-157 profile
Four rules that keep this index independent
- No sales
- We never sell peptides.
- No sellers
- No vendor links, affiliate links or discount codes.
- No doses
- No doses, cycles, stacks or protocols, anywhere.
- No sponsors
- Nobody pays to change a grade.